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Articles » Central nervous system » Holoprosencephaly

2006-11-02-12 Alobar holoprosencephaly © Vavilala



Alobar holoprosencephaly


Suseela Vavilala, MD, Sarada, MD, Bindu, MD

Fernandez Hospital PVT.LTD, Health Care for Woman & the Newborn, Hyderabad, A.P., India 


These are some pictures of 22-year-old primigravida, from non-consanguineous marriage, referred to our hospital at 6th months of pregnancy due to ventriculomegaly. Parents decided for termination of the pregnancy but refused karyotyping. Here are our findings.

Pictures 1, 2, 3 - prenatal ultrasonographic scans of fetal head (1 - fixed retroflexion of the head, iniencephaly, 2 - alobar holoprosencephaly with fused thalami, 3 - ventriculomegaly)


Pictures 4, 5, 6 - comparison of prenatal 2D and 3D coronal scans (4, 5) with pathologic specimen (6)


Pictures 7, 8, 9 - pathologic specimens


Pictures 10, 11 - comparison of prenatal ultrasound finding of hypotelorism with pathologic specimen


Pictures 12, 13 - comparison of prenatal 3D finding of cervical spine (with open neural tube defect) with pathologic specimen


Pictures 14, 15 - comparison of prenatal 3D dysmorphic fetal facies with pathologic specimen (midline cleft lip and palate, low-set hair line) 


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