2017-05-05  Case of the week # 445  © Fabrice Cuillier  www.TheFetus.net

---

Case of the week # 445

May 11, 2017 - May 25, 2017

Cuillier F., MD.*, Alessandri J.L., M.D.*, Balu M.***, Pr Doray B.****.    

 

* Department of Gynecology, Félix Guyon’Hospital, 97400 Saint-Denis, Ile de la Réunion, France. 

** Department of Neonatology, Félix Guyon’Hospital, 97400 Saint-Denis, Réunion. 

*** Department of Radiology, Félix Guyon’Hospital, 97400 Saint-Denis, Réunion. 

**** Department of Cytogenetic, Félix Guyon’Hospital, 97400 Saint-Denis, Réunion. 

 

 

 

Case report

A 26-year old (G1P0)  woman with unremarkable history was referred to our unit.

Our ultrasonographic scan  at 29 weeks of pregnancy and an MRI scan revealed the following findings:
 

 

 

2D Images.

      

 

MRI scan images.

  

When you have tried to solve the case on your own (no team work here please !) you can find the Answer here.

• Other items by Cuillier
• • 3D rendering of normal ears-HTML
    
  • 46XX/47XY + 22 mosaicism-HTML
    
  • 4p- syndrome -HTML
    
  • Abnormal triplet pregnancy -HTML
    
  • Absence of fibula type II -HTML
    
  • Absent hand with digital nubbins-HTML
    
  • Absent pulmonary valve syndrome, 40 weeks-HTML
    
  • Acardiac twin, 25 weeks-HTML
    
  • Acheiria-HTML
    
  • Acheiria-HTML
    
  • Achondrogenesis, type II-HTML
    
  • Acrania-HTML
    
  • Acrania -HTML
    
  • Acrania-HTML
    
  • Acrania-HTML
    
  • Acrania and alobar holoprosencephaly-HTML
    
  • Acrania and cardiac malformation-HTML
    
  • Acrania in one fetus of dichorionic pregnancy-HTML
    
  • Acrania, 14 week, 2D and 3D-HTML
    
  • Acrania, 3D rendering-HTML
    
  • Acrania, 3D rendering-HTML
    
  • Acrania, exencephaly – three cases-HTML
    
  • Adrenal hemorrhage-HTML
    
  • Agenesis of the corpus callosum-HTML
    
  • Agenesis of the corpus callosum-HTML
    
  • Agenesis of the corpus callosum-HTML
    
  • Allantoic cyst-HTML
    
  • Allantoic cyst-HTML
    
  • Allo-immune thrombocytopenia, cerebral hemorrhage-HTML
    
  • Alobar holoprosencephaly-HTML
    
  • Alobar holoprosencephaly and frontal cephalocele-HTML
    
  • Amelia of the upper limbs-HTML
    
  • Amnion rupture -HTML
    
  • Amniotic band syndrome-HTML
    
  • Amniotic band syndrome-HTML
    
  • Amniotic band, 3D rendering-HTML
    
  • Anemia caused by Parvovirus B19 infection-HTML
    
  • Anencephaly -HTML
    
  • Anencephaly-HTML
    
  • Anencephaly, acrania-HTML
    
  • Aortic valve stenosis, endocardial fibroelastosis-HTML
    
  • Aortic valve stenosis, endocardial fibroelastosis, 23 weeks-HTML
    
  • Aorto-pulmonary window-HTML
    
  • Apert syndrome: acrocephalosyndactyly-HTML
    
  • Arachnoid cyst and cleft lip, random association-HTML
    
  • Atrial septal defect, septum primum-HTML
    
  • Atrioventricular septal defect-HTML
    
  • Atypic thoracic cyst.-HTML
    
  • Atypical signs of Beckwith-Wiedemann syndrome-HTML
    
  • Atypical trisomy 18-HTML
    
  • Autosomal dominant polycystic renal disease-HTML
    
  • Autosomal recessive polycystic kidney disease-HTML
    
  • Autosomal recessive polycystic kidney disease-HTML
    
  • Autosomal recessive polycystic kidney disease-HTML
    
  • Axillary lymphangioma -HTML
    
  • Axillary lymphangioma-HTML
    
  • Axillary lymphangioma-HTML
    
  • Beckwith – Wiedemann Syndrome-HTML
    
  • Beckwith–Wiedemann syndrome, omphalocele-HTML
    
  • Benign curved tibia-HTML
    
  • Bilateral cleft lip, 12 weeks-HTML
    
  • Bilateral renal agenesis-HTML
    
  • Binder Syndrome-HTML
    
  • Binder syndrome with brachytelephalangy-HTML
    
  • Bronchogenic cyst-HTML
    
  • Cardiac insufficiency-HTML
    
  • Cardiac insufficiency, cardiomegaly -HTML
    
  • Cardiac rhabdomyoma-HTML
    
  • Cardiac rhabdomyoma (isolated)-HTML
    
  • Case of the week # 332 -Case
  • Case of the week # 313 -Case
  • Case of the week # 314 -Case
  • Case of the week # 318 -Case
  • Case of the week # 319 -Case
  • Case of the week # 320 -Case
  • Case of the week # 323 -Case
  • Case of the week # 338 -Case
  • Case of the week # 345 -Case
  • Case of the week # 366 -Case
  • Case of the week # 378 -Case
  • Case of the week # 395 -Case
  • Case of the week # 398 -Case
  • Case of the week # 405 -Case
  • Case of the week # 406 -Case
  • Case of the week # 417 -Case
  • Case of the week # 431 -Case
  • Case of the week # 441 -Case
  • Case of the week # 442 -Case
  • Case of the week # 446 -Case
  • Case of the week # 453 -Case
  • Case of the week # 457 -Case
  • Case of the week # 463 -Case
  • Case of the week # 469 -Case
  • Case of the week # 470 -Case
  • Case of the week # 63 -Case
  • Case of the week # 99 -Case
  • Case of the week #111 -Case
  • Case of the week #119 -Case
  • Case of the week #125 -Case
  • Case of the week #128 -Case
  • Case of the week #142 -Case
  • Case of the week #144 -Case
  • Case of the week #150 -Case
  • Case of the week #152 -Case
  • Case of the week #153 -Case
  • Case of the week #162 -Case
  • Case of the week #164 -Case
  • Case of the week #165 -Case
  • Case of the week #166 -Case
  • Case of the week #168 -Case
  • Case of the week #177 -Case
  • Case of the week #179 -Case
  • Case of the week #182 -Case
  • Case of the week #186 -Case
  • Case of the week #190 -Case
  • Case of the week #196 -Case
  • Case of the week #203 -Case
  • Case of the week #209 -Case
  • Case of the week #211 -Case
  • Case of the week #219 -Case
  • Case of the week #220 -Case
  • Case of the week #221 -Case
  • Case of the week #225 -Case
  • Case of the week #231 -Case
  • Case of the week #232 -Case
  • Case of the week #236 -Case
  • Case of the week #249 -Case
  • Case of the week #254 -Case
  • Case of the week #273 -Case
  • Case of the week #285 -Case
  • Case of the week #291 -Case
  • Case of the week #302 -Case
  • Case of the week #305 -Case
  • Case of the week #306 -Case
  • Case of the week #315 -Case
  • Cavum vergae cyst-HTML
    
  • Cephalocele, occipital -HTML
    
  • Cerebro-oculo-nasal syndrome-HTML
    
  • Cervical lymphangioma-HTML
    
  • Cervical pregnancy-HTML
    
  • Cervical pregnancy -HTML
    
  • CHARGE syndrome-HTML
    
  • Chiari malformation-HTML
    
  • Choledochal cyst , transient-HTML
    
  • Chondrodysplasia punctata, rhizomelic-HTML
    
  • Chorioangioma-HTML
    
  • Chromosome 15 ring, 46XX,r(15)-HTML
    
  • Chylothorax-HTML
    
  • Cleft lip-HTML
    
  • Cleft lip unilateral, 26 weeks -HTML
    
  • Cleft lip, bilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft lip, unilateral-HTML
    
  • Cleft-lip, unilateral-HTML
    
  • Cleft-lip, unilateral -HTML
    
  • Clitoral hypertrophy-HTML
    
  • Cloacal dysgenesis with imperforated anus-HTML
    
  • Club feet-HTML
    
  • Club feet-HTML
    
  • Club foot, 3D rendering-HTML
    
  • Club-feet, bilateral-HTML
    
  • CMV fetopathy-HTML
    
  • CMV neuropathy-HTML
    
  • Coarctation of the aorta-HTML
    
  • Congenital chloride diarrhea -HTML
    
  • Congenital lobar adenomatosis and amniotic band syndrome-HTML
    
  • Congenital megaurethra-HTML
    
  • Congenital megaurethra, 28 weeks-HTML
    
  • Congenital splenic cyst: report of four cases-HTML
    
  • Congenitally corrected transposition of the great arteries-HTML
    
  • Cord entanglement, twins -HTML
    
  • Cord, velamentous insertion -HTML
    
  • Cornelia de Lange syndrome-HTML
    
  • Corrected transposition of great arteries-HTML
    
  • Cumming syndrome-HTML
    
  • Currarino syndrome, partial form-HTML
    
  • Cystic adenomatoid malformation of the lung-HTML
    
  • Cystic fibrosis and meconium ileus-HTML
    
  • Cystic hygroma, Turner syndrome-HTML
    
  • Cytomegalovirus infection-HTML
    
  • Cytomegalovirus infection-HTML
    
  • Cytomegalovirus infection with lissencephaly in twin pregnancy-HTML
    
  • Cytomegalovirus infection, 23 weeks-HTML
    
  • Cytotrophoblastic cyst-HTML
    
  • Dacryocystocele, 3D rendering-HTML
    
  • Dandy Walker malformation -HTML
    
  • Dandy Walker variant-HTML
    
  • Deletion 22q11.2 syndrome-HTML
    
  • Diaphragmatic hernia-HTML
    
  • Diaphragmatic hernia, absence of fibula and apodia, possible Cornelia de Lange syndrome-HTML
    
  • Distal arthrogryposis -HTML
    
  • Double-outlet right ventricle with a complete atrioventricular septal defect and situs inversus-HTML
    
  • Duodenal and proximal jejunal atresia, 31 weeks-HTML
    
  • Duodenal atresia-HTML
    
  • Duodenal stenosis-HTML
    
  • Duplicated renal collecting system-HTML
    
  • Dysplasic tricuspid valve and subdural hematoma-HTML
    
  • Dysplastic kidneys -HTML
    
  • Ebstein anomaly-HTML
    
  • Ebstein anomaly-HTML
    
  • Ebstein anomaly-HTML
    
  • Ectopic kidney-HTML
    
  • Ectopic kidney, uretero-pelvic junction obstruction-HTML
    
  • Ectopic pregnancies, five different types-HTML
    
  • Ectopic pregnancy, cornual -HTML
    
  • Ectopic pregnancy, tubal -HTML
    
  • Ellis-van Creveld syndrome-HTML
    
  • Endometrial polyps in early pregnancy-HTML
    
  • Extralobar thoracic pulmonary sequestration-HTML
    
  • Female genitalia, 3D scans-HTML
    
  • Femoral - facial syndrome-HTML
    
  • Femoral - facial syndrome -HTML
    
  • Femoral hypoplasia-HTML
    
  • Femoral hypoplasia - unusual facies syndrome-HTML
    
  • Femoral hypoplasia, bilateral-HTML
    
  • Femoral hypoplasia, unilateral-HTML
    
  • Fetal alcohol syndrome-HTML
    
  • Fetal cystadenoma-HTML
    
  • Fetal valproate syndrome-HTML
    
  • Fetal valproate syndrome-HTML
    
  • Fraser syndrome-HTML
    
  • Fryns syndrome-HTML
    
  • Gallstones-HTML
    
  • Gastroschisis -HTML
    
  • Gastroschisis-HTML
    
  • Gastroschisis-HTML
    
  • Gastroschisis-HTML
    
  • Gastroschisis, 3D representation-HTML
    
  • Gastroschisis, 3D representation at 20 weeks-HTML
    
  • Hepatic calcification-HTML
    
  • Hepatic calcifications-HTML
    
  • Heterotopic pregancy with intra-uterine twins-HTML
    
  • Heterotopic pregnancy-HTML
    
  • History, classification, and two cases of conjoined twins-HTML
    
  • Holoprosencephaly-HTML
    
  • Holoprosencephaly, alobar-HTML
    
  • Holt-Oram syndrome-HTML
    
  • Holt-Oram syndrome-HTML
    
  • Hydrocephalus, dysgenesis of the corpus callosum, atrioventricular septal defect-HTML
    
  • Hydrocolpos-HTML
    
  • Hyperechogenicity of myocardium and tricuspid valve-HTML
    
  • Hyperechoic kidneys-HTML
    
  • Hypoplastic kidney, unilateral -HTML
    
  • Hypoplastic kidney, unilateral -HTML
    
  • Hypoplastic kidney, unilateral -HTML
    
  • Hypoplastic left heart syndrome-HTML
    
  • Hypoplastic left heart syndrome-HTML
    
  • Hypoplastic left heart syndrome and left dysplastic kidney-HTML
    
  • Hypoplastic left heart syndrome, 28 weeks-HTML
    
  • Hypoplastic left heart syndrome, 40 weeks-HTML
    
  • Hypospadias-HTML
    
  • Hypospadias-HTML
    
  • Idiopathic cerebral hemorrhage-HTML
    
  • Idiopathic liver calcifications-HTML
    
  • Idiopathic polyhydramnios, cryptorchidy, fetal hypokinesis - possible signs of Prader-Willi syndrome-HTML
    
  • Idiopathic subependymal pseudocyst -HTML
    
  • Idiopathic subependymal pseudocyst-HTML
    
  • Ileal atresia-HTML
    
  • Iniencephaly and acrania-HTML
    
  • Interhemispheric arachnoid cyst -HTML
    
  • Interhemispheric arachnoid cyst-HTML
    
  • Interhemispheric cyst, agenesis of the corpus callosum. -HTML
    
  • Interruption of the aortic arch-HTML
    
  • Intrathoracic bronchogenic cyst-HTML
    
  • Jarcho-Levin syndrome-HTML
    
  • Jarcho-Levin syndrome-HTML
    
  • Jarcho-Levin syndrome with caudal regression-HTML
    
  • Jejunal atresia in a twin gestation -HTML
    
  • Kidney dysplasia-HTML
    
  • Kniest syndrome-HTML
    
  • Larsen - Bourbon syndrome -HTML
    
  • Lethal multiple pterygium syndrome-HTML
    
  • Limb body wall complex-HTML
    
  • Limb body wall complex, 15 weeks of gestation -HTML
    
  • Limb-body wall complex in ectopic pregnancy-HTML
    
  • Liver cyst-HTML
    
  • Lumbosacral myelomeningocele-HTML
    
  • Lung sequestration, extralobar, intrathoracic-HTML
    
  • Lymphangioma, abdominopelvic cystic-HTML
    
  • Male genitalia, 3D scans-HTML
    
  • Maxillo-Nasal dysplasia; Binder syndrome-HTML
    
  • Meckel Gruber syndrome-HTML
    
  • Meckel-Gruber syndrome-HTML
    
  • Megalourethra, 13 weeks-HTML
    
  • Megaureter -HTML
    
  • Megaureter -HTML
    
  • Meningocele with filiform connection-HTML
    
  • Meningocele with filiform connection-HTML
    
  • Meningocele, Cervical Filiform-HTML
    
  • Meningocele, diastematomyelia and syrinx-HTML
    
  • Microcephaly-HTML
    
  • Microcephaly with abnormal gyral pattern-HTML
    
  • Molar pregnancy-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X-HTML
    
  • Monosomy X affecting one of the fetuses of dichorionic twin pregnancy-HTML
    
  • Monosomy X, hygroma colli-HTML
    
  • Monosomy X, hypoplastic left heart-HTML
    
  • Multicystic dysplastic kidney disease, bilateral, 17 weeks-HTML
    
  • Multicystic dysplastic kidney disease, unilateral-HTML
    
  • Multicystic dysplastic kidney disease, unilateral, 32 weeks-HTML
    
  • Multicystic kidney disease -HTML
    
  • Multicystic kidney disease -HTML
    
  • Multicystic kidney disease, 3D representation -HTML
    
  • Multicystic kidney disease, unilateral-HTML
    
  • Multicystic kidney disease, unilateral -HTML
    
  • Multicystic kidney disease, unilateral -HTML
    
  • Multicystic kidney disease, unilateral, in a twin-HTML
    
  • Myelomeningocele-HTML
    
  • Nemaline myopathy-HTML
    
  • Neuroblastoma-HTML
    
  • Neuroblastoma, prenatal regression-HTML
    
  • Noonan syndrome-HTML
    
  • Noonan syndrome-HTML
    
  • Noonan syndrome-HTML
    
  • Noonan syndrome-HTML
    
  • Obstructive uropathy resulting in urinoma formation -HTML
    
  • Occipital cephalocele-HTML
    
  • Occipital encephalocele, 21 weeks-HTML
    
  • Occipital meningocele-HTML
    
  • Occipital meningocele-HTML
    
  • Occipital meningoencephalocele-HTML
    
  • OEIS complex-HTML
    
  • Omphalocele-HTML
    
  • Omphalocele-HTML
    
  • Omphalocele in a twin, 11 weeks-HTML
    
  • Omphalocele, 3D representation -HTML
    
  • Omphalocele, 3D representation -HTML
    
  • Omphalomesenteric cyst-HTML
    
  • Osteogenesis imperfecta, type II-HTML
    
  • Otocephaly - Agnathia - Holoprosencephaly - Acrania-HTML
    
  • Otocephaly-agnathia-holoprosencephaly-HTML
    
  • Ovarian cyst -HTML
    
  • Ovarian cyst-HTML
    
  • Ovarian cyst-HTML
    
  • Ovarian cyst-HTML
    
  • Ovarian cyst-HTML
    
  • Ovarian cyst-HTML
    
  • Ovarian Cyst-HTML
    
  • Ovarian cyst-HTML
    
  • Pallister Killian syndrome -HTML
    
  • Pallister Killian syndrome, 23 weeks-HTML
    
  • Pallister-Killian syndrome-HTML
    
  • Partial agenesis of the corpus callosum and cleft lip-HTML
    
  • Pentalogy of Cantrell, 11 weeks -HTML
    
  • Persistent right umbilical vein-HTML
    
  • Platyspondylic lethal skeletal dysplasia-HTML
    
  • Polydactyly, postaxial -HTML
    
  • Postaxial polydactyly-HTML
    
  • Posterior urethral valves-HTML
    
  • Posterior urethral valves-HTML
    
  • Posterior urethral valves with anhydramnios-HTML
    
  • Posterior urethral valves without anhydramnios, 32 weeks -HTML
    
  • Posterior urethral valves, 15 weeks -HTML
    
  • Posterior urethral valves, 15 weeks-HTML
    
  • Posterior urethral valves, 22 weeks-HTML
    
  • Posterior urethral valves, 32 weeks -HTML
    
  • Posterior urethral valves, 35 weeks -HTML
    
  • Pregnancy in cesarean scar, four cases-HTML
    
  • Prenatal diagnosis of fetal gallstones -HTML
    
  • Proximal femoral deficiency syndrome, bilateral-HTML
    
  • Proximal femoral hypoplasia, unilateral-HTML
    
  • Pseudo-omphalocele-HTML
    
  • Pulmonary Valve Dysplasia-HTML
    
  • Pulmonary valve stenosis with tricuspid regurgitation-HTML
    
  • Pulmonary valve stenosis, moderate-HTML
    
  • Rachischisis-HTML
    
  • Radial aplasia, bilateral, 12-21 weeks-HTML
    
  • Radial ray aplasia-HTML
    
  • Ranula, Benign mucous cyst-HTML
    
  • Renal agenesis, bilateral -HTML
    
  • Renal tubular dysgenesis-HTML
    
  • Renal tubular dysgenesis-HTML
    
  • Retroplacental fibroid-HTML
    
  • Rhabdomyoma-HTML
    
  • Rhabdomyoma-HTML
    
  • Rhabdomyoma-HTML
    
  • Rhabdomyoma of the heart-HTML
    
  • Right atrial isomerism-HTML
    
  • Right axillary lymphangioma-HTML
    
  • Sacrococcygeal teratoma, 26 weeks-HTML
    
  • Sacro-lumbar myelomeningocele-HTML
    
  • Schisis-association-HTML
    
  • Schizencephaly-HTML
    
  • Schizencephaly, type II-HTML
    
  • Sequestration, infradiaphragmatic-HTML
    
  • Sirenomelia-HTML
    
  • Situs invertus, abdominal-HTML
    
  • Spina bifida aperta-HTML
    
  • Spina bifida, lumbar-HTML
    
  • Spina bifida, lumbar-HTML
    
  • Spina bifida, lumbar-HTML
    
  • Spleen calcifications-HTML
    
  • Split hand syndrome-HTML
    
  • Spondylocostal dysplasia (spondylothoracic dysplasia type II)-HTML
    
  • Subamniotic bleeding and hematoma-HTML
    
  • Subependymal pseudocyst-HTML
    
  • Supraventricular tachycardia-HTML
    
  • Tetralogy of Fallot-HTML
    
  • Thoracic lymphangioma-HTML
    
  • Thoracic meningocele - 1º trimester-HTML
    
  • Toxoplasmosis fetopathy-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of great arteries-HTML
    
  • Transposition of the great arteries, ventricular septal defect, and interruption of the aortic arch-HTML
    
  • TRAP, acardiac, acephalus-HTML
    
  • Tricuspid atresia-HTML
    
  • Tricuspid atresia, type I, 23 weeks-HTML
    
  • Tricuspid insufficiency and right atrioventricular hypertrophy with pulmonary atresia-HTML
    
  • Tricuspid valve dysplasia with regurgitation-HTML
    
  • Triploidy-HTML
    
  • Trisomy 13-HTML
    
  • Trisomy 18-HTML
    
  • Trisomy 18-HTML
    
  • Trisomy 18 -HTML
    
  • Trisomy 18-HTML
    
  • Trisomy 18-HTML
    
  • Trisomy 18-HTML
    
  • Trisomy 18, 12 weeks-HTML
    
  • Trisomy 18, 13th week-HTML
    
  • Trisomy 18, diencephalo-rhombencephalic dysplasia-HTML
    
  • Trisomy 21-HTML
    
  • Trisomy 21-HTML
    
  • Trisomy 21 with tricuspid regurgitation-HTML
    
  • Trisomy 21, atrio-ventricular defect-HTML
    
  • Trisomy 21, cystic hygroma-HTML
    
  • Trisomy 21, ventricular septal defect-HTML
    
  • Trisomy 22 mosaicism-HTML
    
  • Truncus arteriosus-HTML
    
  • Twin-to-twin transfusion with corpus callosum lysis after co-twin death-HTML
    
  • Two- and three-dimensional sonography in early diagnosis of limb-body wall complex-HTML
    
  • Umbilical cord cyst imitating omphalocele-HTML
    
  • Umbilical cord entanglement in monoamniotic twins-HTML
    
  • Unilateral acheiria-HTML
    
  • Unilateral anophthalmia and schizencephaly-HTML
    
  • Unilateral cleft lip-HTML
    
  • Unilateral femoral hypoplasia-HTML
    
  • Unilateral femoral hypoplasia (two cases)-HTML
    
  • Unilateral multicystic dysplastic kidney -HTML
    
  • Unilateral multicystic dysplastic kidney-HTML
    
  • Ureterocele -HTML
    
  • Ureterocele-HTML
    
  • Ureterocele, obstructive-HTML
    
  • Urinoma, different etiologies-HTML
    
  • Uterine scar dehiscence-HTML
    
  • VACTERL association-HTML
    
  • VACTERL association-HTML
    
  • Vallecular cyst-HTML
    
  • Vasa praevia-HTML
    
  • Vasa previa-HTML
    
  • Vasa previa-HTML
    
  • Vasa previa with bilobate placenta-HTML
    
  • Vasa previa with bilobate placenta-HTML
    
  • Vasa previa with bipartita placenta-HTML
    
  • Ventricular septal defect -HTML
    
  • Visceral situs inversus-HTML
    
  • Volvulus-HTML
    
  • Wolf-Hirschhorn syndrome-HTML