Trisomy 13 with alobar holoprosencephaly

Khalil Zouiten, MD

Martinique

This is a trisomy 13 fetus seen at 28 weeks. Note the alobar holoprosencephaly with a single ventricle, the hypotelorism, the median cleft lip.

The median cleft lip:

The alobar holoprosencephaly with a single ventricle:

Reconstructions of the face with a mid-facial hypoplasia, absence of the nose and midline cleft lip.

The newborn

These are C and MRI reconstructions demonstrate the same findings.

The alobar holoprosencephaly. Note the horseshoe shape of the single ventricle in both axial and coronal views.