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Nathalie Lassau, MD, PhD
Interest of Dynamic Contrast-Enhanced Ultrasonography (DCE-US) for the Early Evaluation of Anti-Angiogenesis Treatments
Nathalie Lassau, MD, PhD
10/01/2011 | Time : 37 min
About This Lecture:

Topics mentioned in this video : Angiogenic factors, VEGF is key mediator of angiogenesis, Development in oncology, Chart, VEGF inhibitors, RCC, Why do we need tumor functional evaluation?, 2 goals, Clinical experience at IGR, Cited literature, DCE-US and CT scan, Metastatic RCC, Standardization, Quantification, Dynamic acquisition, Modelization, Perfusion parameters, Methodology, Tracking, Focus, Quantification, Other studies, Experience at IGR, Correlation, RCC, RCC and sunitinib, DCE-US after 15 days, Metastasis from RCC, DCE-US at 15 days and 3 months, DCE-US after 6 months, GIST, Phase II: GIST, After 1 month, HCC, HCC treated with Avastin, Sonographic example, Chart, Rare tumors, DCE-US in a responder, DCE-US in a nonresponder, IGR studies, HCC and Avastin, Validation, French national program, Program participants, 650 patients included, Methodology, Last inclusion March 31, 2010, Population, Results, Prediction of RECIST response, RCC metastasis, 1 week, 2 weeks, 1 month, RCC, DCE-US at 1 week, Corresponding contrast uptake curves, Phase I, Baseline, After 1 week, Results, Metastatic colon cancer, Corresponding contrast uptake curves, GIST with hepatic metastasis, GIST treated by Glivec, CT at 4 months, Baseline, 2 months, Breast cancer with hepatic metastasis, D+7 and 2 months, CT at 2 months, Results, Metastatic melanoma, DCE-US after 1 week, D+40, Distribution of quality scores, Quality score, Logistic regression, Summary of cost study, Cost of DCE-US, To build a European and International Network, To create a network for DCE-US methodology, Teaching in the world – guidelines, Conclusion, The next step…

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Keywords : Avastin, breast cancer, CEUS, Colon cancer, contrast enhanced ultrasound agents, contrast wash in, contrast wash out, DCE-US, dynamic contrast enhanced ultrasonography, gastrointestinal stromal tumor, GIST, Glivec, HCC, hepatic cellular carcinoma, hepatic metastasis, hepatic mets, liver metastases, liver mets, mean transit time, melanoma, metastatic breast cancer, metastatic melanoma, metastatic RCC, peak intensity, RCC, RECIST, renal cell carcinoma, response evaluation criteria in solid tumors, SonoVue, temporal resolution, transit time, vascular endothelial growth factor, VEGF inhibitors, VEGF

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