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2018-01-23  Case of the week # 466  © Lusine Karapetyan

Answer to the case of the week # 466
March 15 - March 29, 2018

Lusine Karapetyan, MD

Case report

A 27-year-old women (G1P0) with no remarkable  history  was referred to our unit  for second trimester scan (at 19 weeks 5 days of pregnancy. 
Fetal ultrasound examination revealed the following findings:

-Abnormal shape of the cavum septum pellucidum
-Abnormal midline connection of the cerebral hemispheres with confluence of the posterior horns of the lateral ventricles
-Partia agenesis of the corpus callosum

Based on the ultrasound findings at 20 and 31 weeks of pregnancy, our diagnosis was syntelencephaly, and it was confirmed after birth.

Syntelencephaly is a mild subtype of holoprosencephaly. Is is a rare anomaly consider the 4th type of holoprosencephaly.
For further references follow the link to the COW #262  :

19 weeks

Images 1 and 2
: 2D axial images of the fetal head showing 
fusion of cerebral hemispheres and abnormal shape of the cavum septum pellucidum.


Image 3: tomographics ultrasound imaging showing fusion in the posterior frontal and parietal regions, and abnormal shape of the cavum septum pellucidum.

31 weeks

Images 4 and 5, videos 1, 2 and 3
2D  and Doppler images of the fetal head showing fusion of cerebral hemispheres and abnormal shape of the cavum septum pellucidum. At this gestational age the fusion is better visualized and colpocephaly is better depicted, suggesting an partial agenesis of corpus callosum.

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