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Articles ยป Cardiovascular
 2006-04-24-11Hyperechogenicity of myocardium and tricuspid valve © Cuillier www.thefetus.net/

Hyperechogenicity of myocardium and tricuspid valve

Cuillier F, MD*, Deshayes M**, Lemaire P**, Carasset G, MD***


* Department of Gynecology, ***   Sonogapher, Moufia’street  **  Department of Gynecology, Saint Clothilde Clinic, de la Réunion, France.

Definition: An abnormal calcification in the heart is called a "hyperechogenic focus". In postnatal life, dystrophic calcification of the myocardium is a non-specific reflection of severe myocardial injury. It occurs in areas of necrosis, fibrosis and hemorrhage in the presence of normal serum levels of calcium and phosphorus 1.

Case report: This is a 29-year-old woman, G2P1. The nuchal translucency and the triple test were normal. At 13, 23 and 32 weeks, the fetal scans were normal. At 37 weeks, the patient had some uterine contractions and she came to our unit for a routine scan. A scan revealed an abnormal calcification on the right heart (Figures 1-2-3-4). The calcification was seen in the tricuspid valve (Figure 5-6), which seems dysplastic (Figure 7-8). The screening tests for fetal infection were negative (Rubella, Toxoplasmosis, CMV, Herpes, MNI, Coxsackie, Enterovirus and Chikungunya).

The baby born at 41 weeks (2800g). The cardiac physical exam and the ECG were normal. The postnatal scan confirmed the diagnosis. The left ventricle was normal, but the right myocardium was hypertrophic. There was a tricuspid dysplasia. Indeed the tricuspid valve and the chordae were hyperechoic and dysplastic. The septal valve was against the wall, and the two other tricuspid valves have a normal mobility. Nevertheless the global cardiac function was normal, in particular, the tricuspid function. There was either a normal atrioventricular and ventricular connections. Aorta and pulmonary artery had normal size. At one-month-old, the baby is healthy.

 

Scan at 38 weeks showing prominent echogenicity of the right ventricular wall and echogenic focus within the apical region of the right ventricle

Four chamber view at 38 weeks showing interventricular septal defect (membranous type).

Long axis view at 38 weeks. Note the echogenic focus within the right intraventricular wall. The hyperechogenic outline on the right heart is also demonstrated.

Prevalence: In the fetal life, the majority of pericardium abnormalities involve pericardial effusion and tumors. Vettraino et al described only five cases in more than 170.000 scans in their unit (1). In the other hand, an echogenic focus limited to the myocardium is the more common prenatal finding.  Antenatal, echogenic focus have been found in 5% of second and third trimester fetuses and are generally regarded as a normal variant (2). The neonatal echocardiograms and follow-up studies showed usually normal cardiac anatomy and function.

Pathogenesis: Calcification of the myocardium has been classified as either dystrophic or metastatic.

  • Dystrophic classification is more common and may occur in areas of necrosis, hemorrhage of fibrosis of the myocardium, without abnormal levels of calcium or phosphorus in the blood. The calcium deposition is related to low production of carbon dioxide in slowly metabolizing tissue, with consequent development of a local zone of relative alkalinity and reduced solubility of calcium. Dystrophic calcification occurs in cases of infarction, hypoxia and virus infection (6).
    In adult life, an echogenic pericardium may be related to acute fibrin strands, fibrous connective tissue, tumors, fat, blood clots and calcifications. It can also occur in patients affected by systemics diseases (rheumatics), chronic dialed patients and asbestos workers.
    In fetal life, the origin of echogenic myocardium focus is not clear. Echogenic focus have been described in various anatomic areas of the fetus, especially brain, liver and cardiac papillary muscle (1) and there is a concern for underlying fetal infection, viral or parasitic. Pathology correlates have shown these focus are associated with areas of dystrophic calcification or mineralization.
  • Metastatic calcifications are seen in adult life.